Bertelsen B, Kalvenes M B, Hartveit F
Gade Institute, Department of Pathology, University of Bergen, Haukeland Hospital, Norway.
APMIS. 1996 Dec;104(12):900-6. doi: 10.1111/j.1699-0463.1996.tb04956.x.
Human papillomavirus (HPV) infection is common in cervical intraepithelial neoplasia (CIN) and is widely held to be responsible for its progression to grade 3. This thesis is examined here. Comparison of the level of HPV changes in 133 lesions that had not progressed to that in those from 197 women with histologically proven CIN 3 failed to reveal significant differences in their level of HPV infection on cytology, histology or in situ hybridization. However, in both these groups, some of the cases that did not show HPV positivity on in situ hybridization with probes reacting with the common HPV types did show evidence of HPV DNA using a general primer-mediated polymerase chain reaction. This may indicate low-copy number infections or non-productive infections. Such reactions were more frequent in the women with progressive lesions, and it is probable that they may also have been at greater risk of cervical infection in general. The present findings suggest that a further factor, a cocarcinogen, may be involved in progression to CIN 3, HPV being a common forerunner, providing a proliferative environment and thus favoring such an event.
人乳头瘤病毒（HPV）感染在宫颈上皮内瘤变（CIN）中很常见，并且普遍认为它是导致其进展为3级的原因。本文对此进行了研究。对133例未进展的病变与197例经组织学证实为CIN 3的病变中HPV变化水平进行比较，结果发现在细胞学、组织学或原位杂交方面，它们的HPV感染水平没有显著差异。然而，在这两组中，一些与常见HPV类型反应的探针进行原位杂交时未显示HPV阳性的病例，使用通用引物介导的聚合酶链反应确实显示出HPV DNA的证据。这可能表明存在低拷贝数感染或非生产性感染。这种反应在有进展性病变的女性中更常见，并且她们总体上也可能有更高的宫颈感染风险。目前的研究结果表明，可能还有另一个因素，即促癌物，参与了进展为CIN 3的过程，HPV是常见的前驱因素，提供了一个增殖环境，从而促进了这一过程。
