Jensen H E, Aalbaek B, Hau J, Latgé J P
Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
APMIS. 1996 Dec;104(12):926-32. doi: 10.1111/j.1699-0463.1996.tb04960.x.
Foeto-placental infections are obtained when pregnant mice are challenged intravenously with conidial suspensions of Aspergillus fumigatus. This experimental model, which is used without any immuno-suppressive pretreatment, can be employed to screen for differences in foeto-placental infectivity of A. fumigatus strains when the number of colony-forming units (CFUs) in conidial suspensions used for infection is from 1 x 10(5) to 1 x 10(6). In the foeto-placental unit, hyphal growth was initiated at the periphery of the placental disc from which infection spread to the central parts of the placenta, the extrafoetal membranes and the foetus. Complement activation was noticed as a consequence of pregnancy and conidial inoculation, but was neither dose-dependent nor related to the extent of infection. Galactomannan was present in the plasma of infected mice and, in contrast to the situation in bovine placental aspergillosis, can be used as a good marker of foeto-placental aspergillosis.
当给怀孕小鼠静脉注射烟曲霉分生孢子悬液时，可导致胎儿-胎盘感染。该实验模型无需任何免疫抑制预处理，当用于感染的分生孢子悬液中的菌落形成单位（CFU）数量为1×10⁵至1×10⁶时，可用于筛选烟曲霉菌株在胎儿-胎盘感染性方面的差异。在胎儿-胎盘单元中，菌丝生长始于胎盘盘的周边，感染从这里扩散到胎盘的中央部分、胎儿外膜和胎儿。由于怀孕和分生孢子接种，补体激活被注意到，但既不依赖剂量也与感染程度无关。半乳甘露聚糖存在于受感染小鼠的血浆中，与牛胎盘曲霉菌病的情况不同，它可用作胎儿-胎盘曲霉菌病的良好标志物。
