Jensen H E, Hau J
Department of Veterinary Pathology, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
In Vivo. 1990 Jul-Aug;4(4):247-52.
Primipregnant BALB/cABom mice were challenged intravenously with 1 x 10(5) Aspergillus fumigatus conidia on day 10 of pregnancy. Histopathological examination of the foeto-placental units and extrauterine organs from the mice revealed hyphal growth restricted to the foeto-placental unit. In the foeto-placental unit the growth of hyphae was first established on Reicher's membrane next to the periphery of the placental disc. Subsequently hyphae spread along and through the extrafoetal membranes, finally reaching the foetus. In the terminal stage of infection mycosis also ensued in the placental discs. In conclusion, A. fumigatus was found to have a propensity for infecting the murine foeto-placental unit, resulting in mycotic placentitis. This series of events seems comparable to the progression of the spontaneous disease in cattle. Consequently, the pregnant mouse seems applicable as an animal model for the study of mycotic placentitis due to A. fumigatus, which in most countries is of great importance in cattle breeding.
在妊娠第10天，对初孕的BALB/cABom小鼠进行静脉注射1×10⁵ 烟曲霉菌分生孢子。对这些小鼠的胎儿-胎盘单位和子宫外器官进行组织病理学检查发现，菌丝生长仅限于胎儿-胎盘单位。在胎儿-胎盘单位中，菌丝首先在胎盘盘边缘附近的赖歇膜上生长。随后，菌丝沿着并穿过胎膜扩散，最终到达胎儿。在感染的末期，胎盘盘中也发生了霉菌病。总之，发现烟曲霉菌倾向于感染小鼠胎儿-胎盘单位，导致霉菌性胎盘炎。这一系列事件似乎与牛的自发性疾病进展相似。因此，怀孕小鼠似乎可作为研究由烟曲霉菌引起的霉菌性胎盘炎的动物模型，而在大多数国家，烟曲霉菌在牛的繁殖中具有重要意义。
