Engel U, Breborowicz D, Albrectsen J M, Bøg-Hansen T C, Francis D
Department of Pathology, Bispebjerg Hospital, University of Copenhagen, Denmark.
APMIS. 1996 Dec;104(12):933-7. doi: 10.1111/j.1699-0463.1996.tb04961.x.
There are conflicting results respecting the segmental tubular origin of renal oncocytomas, a type of tumour said to be highly differentiated and benign, though metastases have been described. The aim of this study was, by applying different lectins on renal cell carcinomas (n = 50) and oncocytomas (n = 12), to search for patterns which could indicate a specific segmental origin of oncocytomas and perhaps elucidate the differentiation of this tumour. The following lectins were applied: jacalin, peanut agglutinin (PNA), wheat germ agglutinin (WGA), phytohemagglutinin E (PHA-E), concanavalin A (Con A), and Dolichos biflorus agglutinin (DBA). The results show that oncocytomas are positive when jacalin, a Lectin that stains distal tubules and collecting tubules, is used, supporting the view that the tumour derives from distal or collecting tubules. The staining of the oncocytomas is generally polarized as in normal kidney tubules underlining that the tumour is highly differentiated. Two oncocytomas with aggressive behaviour showed areas with a diffuse pattern suggesting lower differentiation.
关于肾嗜酸细胞瘤的节段性肾小管起源存在相互矛盾的结果。肾嗜酸细胞瘤是一种据说高度分化且为良性的肿瘤，不过也有转移的报道。本研究的目的是，通过对肾细胞癌（n = 50）和嗜酸细胞瘤（n = 12）应用不同的凝集素，寻找能够表明嗜酸细胞瘤特定节段起源的模式，并可能阐明该肿瘤的分化情况。应用了以下凝集素：红豆凝集素、花生凝集素（PNA）、麦胚凝集素（WGA）、植物血凝素E（PHA - E）、刀豆球蛋白A（Con A）和双花扁豆凝集素（DBA）。结果显示，当使用能使远端小管和集合小管染色的凝集素红豆凝集素时，嗜酸细胞瘤呈阳性，这支持了该肿瘤起源于远端或集合小管的观点。嗜酸细胞瘤的染色通常像正常肾小管一样呈极化状态，这突出表明该肿瘤高度分化。两个具有侵袭性行为的嗜酸细胞瘤显示出弥漫性模式的区域，提示分化程度较低。
