编码AAA家族两个单结构域人类成员的基因定位：PSMC5（甲状腺激素受体相互作用蛋白，TRIP1）和PSMC3（Tat结合蛋白，TBP1）。

Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1).

作者信息

Hoyle J, Tan K H, Fisher E M

机构信息

Neurogenetics Unit, Imperial College School of Medicine at St. Mary's, London, UK.

出版信息

Hum Genet. 1997 Feb;99(2):285-8. doi: 10.1007/s004390050356.

DOI:10.1007/s004390050356

PMID:9048938

Abstract

The eukaryotic genome contains a putative AT-Pase gene family that encodes proteins with one or two highly conserved domain(s) of approximately 230 amino acids. These proteins have diverse cellular functions and mutation in at least one member of the family has been associated with human disease, while mutations in other family members are known to cause cell cycle defects in yeast. Therefore it is of interest to map more family members and so we have localized PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1) to chromosomes 17q24-q25 and 11p12-p13, respectively. We also present the map position of a probable PSMC3 processed pseudogene locus on chromosome 9p.

摘要

真核生物基因组包含一个推测的ATP酶基因家族，该家族编码的蛋白质具有一个或两个约230个氨基酸的高度保守结构域。这些蛋白质具有多种细胞功能，该家族中至少一个成员的突变与人类疾病相关，而其他家族成员的突变已知会导致酵母细胞周期缺陷。因此，绘制更多家族成员图谱很有意义，我们已将PSMC5（甲状腺激素受体相互作用蛋白，TRIP1）和PSMC3（Tat结合蛋白，TBP1）分别定位到17q24-q25和11p12-p13染色体上。我们还给出了9p染色体上一个可能的PSMC3加工假基因位点的图谱位置。