Zaaroor M, Starr A
Department of Neurosurgery, Ramborn Medical Center Faculty of Medicine, Technion, Haifa, Israel.
Acta Neurol Scand. 1997 Jan;95(1):19-22. doi: 10.1111/j.1600-0404.1997.tb00062.x.
The objective of this study was to describe facial myokymia in experimental animals accompanying kainic acid affects on facial motor neurons.
MATERIAL & METHODS: Anesthetized cats were injected with kainic acid into the pons adjacent to the facial nucleus. Facial movements appeared shortly after the injections and facial electromyographic potentials were recorded. Cats were killed up to 4 weeks later, the brainstems were processed histologically, and the number of neurons in the facial nucleus counted.
Cats receiving injection of kainic acid adjacent to facial nucleus all developed spontaneous writhing movements of the face ipsilateral to the injection site, clinically resembling facial myokymia in humans. Transient facial paresis, lasting several weeks, appeared in some of the cats. Facial myokymia occurred independent of histological evidence of neuronal loss in facial nucleus, whereas facial paresis occurred in all but one of the animals with significant neuronal loss in the facial nucleus. Placing a needle into the superior olive without injecting kainic acid or injections of kainic acid into cochlear nucleus was not accompanied by facial myokymia or subsequent facial paresis.
Facial movements in cats similar to myokymia in humans accompanies kainic acid injections adjacent to the nucleus of the facial nerve.
本研究的目的是描述实验动物中伴随海人酸对面部运动神经元影响的面部肌束震颤。
对麻醉后的猫在面神经核附近的脑桥注射海人酸。注射后不久出现面部运动，并记录面部肌电图电位。在长达4周后处死猫，对脑干进行组织学处理，并对面神经核中的神经元数量进行计数。
在面神经核附近注射海人酸的猫均出现注射部位同侧面部的自发扭动运动，在临床上类似于人类的面部肌束震颤。一些猫出现了持续数周的短暂性面瘫。面部肌束震颤的发生与面神经核中神经元丢失的组织学证据无关，而面瘫发生在除一只外的所有面神经核有明显神经元丢失的动物中。将针插入上橄榄核而不注射海人酸或在耳蜗核注射海人酸均未伴有面部肌束震颤或随后的面瘫。
在面神经核附近注射海人酸会使猫出现类似于人类肌束震颤的面部运动。
