Strand A, Wilander E, Zehbe I, Rylander E
Department of Dermatology, University Hospital, Uppsala, Sweden.
Acta Obstet Gynecol Scand. 1997 Feb;76(2):140-4. doi: 10.3109/00016349709050070.
Knowledge about the natural course of HPV infection is still limited. In this study we investigated the presence of HPV DNA after treatment and clinical clearance of infection.
Eighty-two women treated for genital HPV infection at the STD clinic in Uppsala were consecutively selected for the study. After treatment with podophyllotoxin, and in some cases laser vaporization, a cell sample was taken at the follow-up visit 6-12 months after clinical clearance of the lesions as evaluated by colposcopy. Samples were analysed with PCR to detect HPV DNA. As a reference group, women treated for cervical intraepithelial neoplasia (CIN) with laser surgery, either with cone biopsy or vaporization, were followed-up after 6 months for the presence of HPV DNA.
Six to 12 months after clinical clearance of HPV infection, 39 (48%) of the women showed detectable HPV DNA in cell samples from the cervix. Of these, 26 (67%) were found to harbor high risk HPV, six (15%) low risk, and seven (18%) either had more than one HPV type or HPV that could not be classified. All but three of the women treated for CIN (90%) were negative for HPV DNA.
After clinical clearance of genital HPV infection half of the women had detectable HPV DNA. This does not necessarily imply that transmission to a new partner may occur, but indicates this possibility. Only 10% of the CIN treated women harbored HPV DNA in the cell samples in spite of showing high risk HPV infection before treatment.
关于人乳头瘤病毒（HPV）感染自然病程的知识仍然有限。在本研究中，我们调查了治疗后HPV DNA的存在情况以及感染的临床清除情况。
连续选取在乌普萨拉性传播疾病诊所接受生殖器HPV感染治疗的82名女性作为研究对象。在用鬼臼毒素治疗后，部分病例采用激光汽化治疗，在通过阴道镜评估病变临床清除后的6至12个月随访时采集细胞样本。采用聚合酶链反应（PCR）分析样本以检测HPV DNA。作为参照组，对接受激光手术治疗宫颈上皮内瘤变（CIN）的女性（采用锥形活检或汽化治疗）在6个月后随访HPV DNA的存在情况。
HPV感染临床清除后的6至12个月，39名（48%）女性的宫颈细胞样本中检测到可检测的HPV DNA。其中，26名（67%）被发现携带高危型HPV，6名（15%）为低危型，7名（18%）携带不止一种HPV类型或无法分类的HPV。除3名接受CIN治疗的女性外，其余所有女性（90%）的HPV DNA检测均为阴性。
生殖器HPV感染临床清除后，半数女性的HPV DNA可检测到。这不一定意味着会发生传染给新伴侣的情况，但表明了这种可能性。尽管治疗前显示为高危型HPV感染，但接受CIN治疗的女性中只有10%的细胞样本中携带HPV DNA。
