Greco P, Cormio G, Vimercati A, Nacci G, di Vagno G, Loverro G, Selvaggi L
Department of Obstetrics and Gynecology, University of Bari, Italy.
Acta Obstet Gynecol Scand. 1997 Feb;76(2):169-72. doi: 10.3109/00016349709050075.
To evaluate the role of transvaginal color Doppler ultrasound in monitoring the response to neoadjuvant chemotherapy in patients with locally-advanced cervical cancer.
Fourteen patients with locally-advanced cervical cancer, scheduled for neoadjuvant chemotherapy, were investigated with transvaginal color Doppler ultrasonography before and at the completion of chemotherapy in order to study hemodynamic changes in cervical and intratumoral vessels. Twenty healthy women matched for age and parity served as a control group. Statistical analysis was performed with Student's t test for paired data.
Statistically different blood flow recording between patients with cervical cancer and healthy controls could be observed only in intratumoral vessels. A significant increase of RI and PI values, recorded in both cervical artery and intratumoral vessels, have been observed in the group of patients responding to neoadjuvant chemotherapy. In patients with stable disease at the completion of chemotherapy, flow characteristics did not change significantly.
Preliminary results of our study suggest that transvaginal color Doppler ultrasound evaluation of flow characteristics in the cervical and intratumoral vessels might be useful in monitoring the response to neoadjuvant chemotherapy in patients with invasive cervical cancer.
评估经阴道彩色多普勒超声在监测局部晚期宫颈癌患者新辅助化疗反应中的作用。
对14例计划接受新辅助化疗的局部晚期宫颈癌患者在化疗前及化疗结束时进行经阴道彩色多普勒超声检查，以研究宫颈及肿瘤内血管的血流动力学变化。选取20名年龄和孕产次匹配的健康女性作为对照组。采用配对数据的t检验进行统计学分析。
仅在肿瘤内血管中观察到宫颈癌患者与健康对照组之间血流记录存在统计学差异。在对新辅助化疗有反应的患者组中，观察到宫颈动脉和肿瘤内血管的阻力指数（RI）和搏动指数（PI）值显著增加。化疗结束时病情稳定的患者，血流特征无明显变化。
我们研究的初步结果表明，经阴道彩色多普勒超声评估宫颈及肿瘤内血管的血流特征可能有助于监测浸润性宫颈癌患者对新辅助化疗的反应。
