Alcázar J L, Castillo G, Jurado M, López-García G
Department of Obstetrics and Gynecology, Clínica Universitaria de Navarra, School of Medicine, University of Navarra, Pamplona, Spain.
Int J Gynecol Cancer. 2003 Jul-Aug;13(4):510-4. doi: 10.1046/j.1525-1438.2003.13302.x.
The objective of this study was to evaluate whether intratumoral blood flow as assessed by transvaginal color Doppler ultrasonography (TVCD) correlates with some tumor features in cervical cancer. Clinical, sonographic, and histologic data on 49 women (mean age: 50.3 years, range: 25-85 years) diagnosed as having a carcinoma from the uterine cervix were reviewed. Intratumoral blood flow was assessed by TVCD in all cases. Subjective impression of the amount of flow (scanty, moderate, or abundant) as well as the lowest resistance index (RI) and highest peak systolic velocity (PSV, cm/s) were used for analysis. These data were correlated with some tumoral features such as histologic type, histologic grade, tumor volume, and tumor stage. Intratumoral blood flow was found in all cases. Abundant blood flow was found more frequently in squamous carcinoma, moderately or poorly differentiated tumors, tumors with larger volume, and advanced stage tumors (P < 0.0001). Significantly lower RI was found in moderately or poorly differentiated tumors and advanced stage tumors (P < 0.01) and significantly higher PSV was found in moderately or poorly differentiated tumors, tumors with larger volume, and advanced stage tumors (P < 0.01). No correlation was found between RI and PSV and histologic type. Our data indicate that intratumoral blood flow as assessed by TVCD correlates well with some tumor features in cervical cancer.
本研究的目的是评估经阴道彩色多普勒超声检查（TVCD）所评估的肿瘤内血流是否与宫颈癌的某些肿瘤特征相关。回顾了49例（平均年龄：50.3岁，范围：25 - 85岁）被诊断为子宫颈癌的女性的临床、超声和组织学数据。所有病例均通过TVCD评估肿瘤内血流。采用血流程度的主观印象（稀少、中等或丰富）以及最低阻力指数（RI）和最高收缩期峰值速度（PSV，cm/s）进行分析。这些数据与一些肿瘤特征相关，如组织学类型、组织学分级、肿瘤体积和肿瘤分期。所有病例均发现肿瘤内血流。丰富血流在鳞状细胞癌、中分化或低分化肿瘤、体积较大的肿瘤以及晚期肿瘤中更常见（P < 0.0001）。中分化或低分化肿瘤以及晚期肿瘤的RI显著较低（P < 0.01），中分化或低分化肿瘤、体积较大的肿瘤以及晚期肿瘤的PSV显著较高（P < 0.01）。未发现RI和PSV与组织学类型之间存在相关性。我们的数据表明，通过TVCD评估的肿瘤内血流与宫颈癌的某些肿瘤特征密切相关。
