McIlhatton M A, Curran M D, Rima B K
School of Biology and Biochemistry, The Queen's University of Belfast, Northern Ireland, UK.
J Gen Virol. 1997 Mar;78 ( Pt 3):571-6. doi: 10.1099/0022-1317-78-3-571.
This paper corrects the previously published sequence of the L gene of canine distemper virus (CDV). Errors in the published sequence (M. S. Sidhu et al., 1993, Virology 193, 50-65) led to frame shifts between residues 1021-1032, 1190-1219 and 1645-1650; a deletion of 21 amino acids between residues 1684-1705, and a single residue deletion at residue 1478. Residue 237 is now found to be glycine rather than tryptophan and residue 1626 proline instead of threonine. The sequence of the L gene of phocine distemper virus (PDV) was also determined. Alignment of the morbillivirus L proteins showed that PDV and CDV are more closely related to each other than to rinderpest virus and measles virus. Two regions of low identity are proposed to function as hinge regions between three highly conserved domains (I-III) in the morbillivirus L proteins. New sequence motifs have been identified on the basis of conservation in the morbilliviruses and the Paramyxovirinae.
本文校正了先前发表的犬瘟热病毒（CDV）L基因序列。已发表序列（M. S. 西杜等人，1993年，《病毒学》193卷，第50 - 65页）中的错误导致了1021 - 1032位、1190 - 1219位和1645 - 1650位残基之间的移码；1684 - 1705位残基之间缺失21个氨基酸，以及1478位残基处缺失单个残基。现已发现237位残基是甘氨酸而非色氨酸，1626位残基是脯氨酸而非苏氨酸。还确定了海豹瘟热病毒（PDV）L基因的序列。麻疹病毒属L蛋白的比对显示，PDV和CDV彼此之间的关系比它们与牛瘟病毒和麻疹病毒的关系更为密切。有人提出，低同源性的两个区域在麻疹病毒属L蛋白的三个高度保守结构域（I - III）之间起铰链区的作用。基于麻疹病毒和副粘病毒亚科中的保守性，已鉴定出了新的序列基序。
