塔斯马尼亚岛和英格兰东北部人群中补体成分C4、C3、C2和BF的同种异型

Allotypes of complement components C4, C3, C2 and BF in the populations of Tasmania and northeast England.

作者信息

Ad'Hiah A H, Mitchell J, Papiha S S

机构信息

Department of Human Genetics, University of Newcastle upon Tyne, U.K.

出版信息

Gene Geogr. 1996 Aug;10(2):93-103.

PMID:9049619

Abstract

The distribution of four serum complement component polymorphisms (BF, C2, C3 and C4) were examined in two geographically separated populations, one from Tasmania (Australia) and the other from northeast England. The differences in genotypic frequencies between them at all 4 loci are not statistically significant (p > 0.05). When C4 haplotypes were investigated, only one (C4A4-C4B2) exhibited significant linkage disequilibrium (p = 0.0006 after correction, p = 0.01), and this was only observed in Tasmanians. The English population exhibited a larger number of alleles across the four loci used in this study than the Tasmanian, and this may well reflect a bottle-neck effect and the greater relative isolation of the population of the island State of Australia. Overall, the findings confirm the close relationship between immigrants from the British Isles to Tasmania.

摘要

在两个地理上分隔的人群中检测了四种血清补体成分多态性（BF、C2、C3和C4）的分布情况，一组来自塔斯马尼亚岛（澳大利亚），另一组来自英格兰东北部。在所有4个基因座上，这两组人群之间的基因型频率差异无统计学意义（p>0.05）。在研究C4单倍型时，仅有一种单倍型（C4A4-C4B2）表现出显著的连锁不平衡（校正后p = 0.0006，p = 0.01），且仅在塔斯马尼亚人群中观察到。在本研究使用的四个基因座上，英格兰人群比塔斯马尼亚人群表现出更多的等位基因，这很可能反映了瓶颈效应以及澳大利亚这个岛屿州人群相对更大程度的隔离。总体而言，这些发现证实了从英伦诸岛移民到塔斯马尼亚的人群之间的密切关系。