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精神分裂症患者中人类白细胞抗原Ⅲ类(C2、BF和C4)同种异型的研究。

Investigation of allotypes of HLA class III (C2, BF and C4) in patients with schizophrenia.

作者信息

Wang C, Jian B X, Jiang X D, Zhao X Z

机构信息

Sino-Australia Friendship Laboratory of Complement, Tongji Medical University, Wuhan.

出版信息

Chin Med J (Engl). 1992 Apr;105(4):316-8.

PMID:1618015
Abstract

The allotypes of HLA Class III (C2, BF and C4) in 60 patients with schizophrenia were investigated. Significantly higher frequencies of BFF, BFSO7 and C4A*4 in patients were found as compared with those of the normal controls. The relative risks (RR) of the three allotypes to schizophrenia were 1.81, 7.79 and 4.18 and the etiologic fraction (EF) were 0.086, 0.060 and 0.042, respectively. There were no significant changes of C2 allotypes.

摘要

对60例精神分裂症患者的HLAⅢ类(C2、BF和C4)同种异型进行了研究。与正常对照组相比,患者中BFF、BFSO7和C4A*4的频率显著更高。这三种同种异型对精神分裂症的相对风险(RR)分别为1.81、7.79和4.18,病因分数(EF)分别为0.086、0.060和0.042。C2同种异型无显著变化。

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