晚期癌症患者血浆中内源性肿瘤坏死因子α浓度的波动
Fluctuation of endogenous TNF alpha concentration in plasma in advanced cancer patients.
作者信息
Muc-Wierzgoń M, Madej K, Baranowski M, Kokot T
机构信息
5th Department of Internal Medicine, Silesian Medical University, Bytom, Poland.
出版信息
J Biol Regul Homeost Agents. 1996 Jan-Mar;10(1):25-6.
OBJECTIVES
To test the hypothesis of a fluctuation of circulating levels of endogenous Tumor Necrosis Factor alpha (TNF alpha) in patients with advanced gastrointestinal cancer.
METHODS
Serum levels of TNF alpha were measured at 8 a.m., 3 p.m., midnight and 3 a.m. in 21 patients with advanced cancer.
RESULTS
Serum TNF alpha levels were substantially increased in patients with advanced cancer as compared to healthy subjects. Peak value appeared at 3 a.m., and gradually declined to very low levels in the afternoon (3 p.m.). Using cosinor least square methods we could not find the circadian rhythm of TNF alpha.
目的
检验晚期胃肠道癌患者体内内源性肿瘤坏死因子α（TNFα）循环水平波动的假说。
方法
对21例晚期癌症患者在上午8点、下午3点、午夜及凌晨3点测量血清TNFα水平。
结果
与健康受试者相比，晚期癌症患者血清TNFα水平显著升高。峰值出现在凌晨3点，下午（下午3点）逐渐降至极低水平。使用余弦分析最小二乘法，我们未发现TNFα的昼夜节律。
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