晚期胃肠道癌患者血浆中肿瘤坏死因子α与可溶性p - 55受体水平之间是否存在相关性？

Is there a correlation between tumor necrosis factor alpha and soluble p-55 receptor plasma levels in advanced gastrointestinal cancer patients?

作者信息

Muc-Wierzgoń M, Madej K, Baranowski M, Wierzgoń J

机构信息

5th Department of Internal Diseases, Silesian Medical Academy, Bytom, Poland.

出版信息

J Biol Regul Homeost Agents. 1996 Oct-Dec;10(4):95-7.

PMID:9604778

Abstract

UNLABELLED

Studies have shown an increased spontaneous TNF alpha production, and the 24--rhythmicity of TNF blood concentration in patients with advanced cancer. The present study investigates whether diurnal rhythmicity of endogenous TNF alpha is associated with the induction of circulating sTNF Rp55 in advanced gastrointestinal neoplasm. The levels of endogenous TNF alpha and sTNF Rp55 in serum were measured at 8 a.m., 2 p.m., 6 p.m., 10 p.m., 2 a.m., and again at 8 a.m.

RESULTS

There is circadian rhythm in the secretion of endogenous TNF alpha in patients with advanced gastrointestinal cancer, however no diurnal rhythm of sTNF Rp55 was observed. Since it has been suggested that human tumors susceptible to TNF alpha may escape destruction by secreting or inducing the secretion of sTNF Rp55 to block the effects of TNF alpha, the possibility that the observed fluctuations could also reflect the complexation of a proportion of the receptor molecules with their ligand should be considered.

摘要

未标记

研究表明，晚期癌症患者自发产生的肿瘤坏死因子α（TNFα）增加，且TNF血液浓度具有24小时节律性。本研究调查晚期胃肠道肿瘤患者内源性TNFα的昼夜节律是否与循环可溶性TNF受体p55（sTNF Rp55）的诱导有关。于上午8点、下午2点、下午6点、晚上10点、凌晨2点测量血清中内源性TNFα和sTNF Rp55的水平，并于次日上午8点再次测量。