Kornman K S, Crane A, Wang H Y, di Giovine F S, Newman M G, Pirk F W, Wilson T G, Higginbottom F L, Duff G W
Medical Science Systems, Inc., San Antonio, TX 78216, USA.
J Clin Periodontol. 1997 Jan;24(1):72-7. doi: 10.1111/j.1600-051x.1997.tb01187.x.
Although specific bacteria, dental plaque, and age are associated with periodontal disease, there are currently no reliable predictors of periodontitis severity. Studies in twins have suggested a genetic contribution to the pathogenesis of periodontitis, but previous attempts to identify genetic markers have been unsuccessful. The pro-inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) are key regulators of the host responses to microbial infection. IL-1 is also a major modulator of extracellular matrix catabolism and bone resorption. We report a specific genotype of the polymorphic IL-1 gene cluster that was associated with severity of periodontitis in non-smokers, and distinguished individuals with severe periodontitis from those with mild disease (odds ratio 18.9 for ages 40-60 years). Functionally, the specific periodontitis-associated IL-1 genotype comprises a variant in the IL-1B gene that is associated with high levels of IL-1 production. In smokers severe disease was not correlated with genotype. In this study, 86.0% of the severe periodontitis patients were accounted for by either smoking or the IL-1 genotype. This study demonstrates that specific genetic markers, that have been associated with increased IL-1 production, are a strong indicator of susceptibility to severe periodontitis in adults.
尽管特定细菌、牙菌斑和年龄与牙周疾病相关，但目前尚无可靠的牙周炎严重程度预测指标。对双胞胎的研究表明，遗传因素在牙周炎发病机制中起作用，但此前识别遗传标记的尝试均未成功。促炎细胞因子白细胞介素-1（IL-1）和肿瘤坏死因子α（TNFα）是宿主对微生物感染反应的关键调节因子。IL-1也是细胞外基质分解代谢和骨吸收的主要调节因子。我们报告了一种多态性IL-1基因簇的特定基因型，它与非吸烟者牙周炎的严重程度相关，可将重度牙周炎患者与轻度患者区分开来（40至60岁人群的优势比为18.9）。在功能上，与牙周炎相关的特定IL-1基因型包含IL-1B基因中的一个变体，该变体与高水平的IL-1产生相关。在吸烟者中，严重疾病与基因型无关。在本研究中，86.0%的重度牙周炎患者可归因于吸烟或IL-1基因型。这项研究表明，与IL-1产生增加相关的特定遗传标记是成年人易患重度牙周炎的有力指标。
