Gundelly Mrunalini, Pusuluri Santosh V, Koduganti Rekha R, Ambati Manasa, Chiluveru Sneha, Chandaka Meenakshi
Periodontics, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Hyderabad, IND.
Cureus. 2024 Sep 8;16(9):e68952. doi: 10.7759/cureus.68952. eCollection 2024 Sep.
Periodontitis, a widespread health issue, requires effective prevention and management strategies due to its increasing prevalence and detrimental social consequences. The chronic inflammation associated with periodontitis also exacerbates systemic conditions, emphasizing the need for advanced approaches in addressing this public health concern. The traditional methods of periodontal diagnosis, which primarily rely on clinical indicators such as pocket depth, clinical attachment loss, mobility, and radiographic measurements of alveolar bone loss, have limitations in guiding therapy due to the intricate and multifaceted nature of periodontal diseases. Precision periodontics is the amalgamation of genomics, bioinformatics, and advanced technology, mainly biomarkers reflecting a precise patient-centered treatment. However, implementing this approach in periodontology is new due to the lack of validated periodontal biomarkers for diagnostic use. This article explores the foundations of personalized therapy in periodontal diagnosis. It discusses the current state and prospects of periodontal biomarkers as a crucial step toward realizing a precision approach in periodontal practice.
牙周炎是一个普遍存在的健康问题，由于其患病率不断上升以及有害的社会后果，需要有效的预防和管理策略。与牙周炎相关的慢性炎症还会加剧全身性疾病，这凸显了采用先进方法来解决这一公共卫生问题的必要性。传统的牙周诊断方法主要依赖于临床指标，如牙周袋深度、临床附着丧失、牙齿松动度以及牙槽骨丧失的影像学测量，由于牙周疾病的复杂性和多面性，这些方法在指导治疗方面存在局限性。精准牙周病学是基因组学、生物信息学和先进技术的融合，主要是通过生物标志物来实现以患者为中心的精准治疗。然而，由于缺乏经过验证的用于诊断的牙周生物标志物，在牙周病学中实施这种方法尚属新颖。本文探讨了牙周诊断中个性化治疗的基础。它讨论了牙周生物标志物的现状和前景，这是在牙周实践中实现精准方法的关键一步。
