Bindal A K, Blisard K S, Melin-Aldama H, Warnick R E
Department of Neurosurgery, University of Cincinnati Medical Center, Ohio, USA.
J Neurooncol. 1997 Feb;31(3):267-71. doi: 10.1023/a:1005769406324.
In patients with acquired immunodeficiency syndrome (AIDS), primary central nervous system lymphoma (PCNSL) is now the most common noninfectious intracranial mass lesion and the fourth leading cause of death. Most cases of PCNSL are B-cell in origin and are only rarely of T-cell origin. We report the first complete clinical description of T-cell PCNSL in a patient with AIDS. This patient underwent stereotactic biopsy of a cerebellar lesion that demonstrated T-cell lymphoma by immunohistochemical staining. The patient died from opportunistic infection after partial radiation therapy. Complete autopsy revealed no evidence of residual T-cell lymphoma. The authors compare T-cell PCNSL in patients with and without AIDS, and discuss differences between T-cell and B-cell PCNSL. In conclusion, T-cell PCNSL can occur in patients with AIDS. The tumor is often located infratentorially and appears to be radiosensitive. However, the patient's survival is short because death is usually caused by opportunistic infection rather than mass effect from lymphoma.
在获得性免疫缺陷综合征（AIDS）患者中，原发性中枢神经系统淋巴瘤（PCNSL）目前是最常见的非感染性颅内肿块病变，也是第四大死亡原因。大多数PCNSL病例起源于B细胞，很少起源于T细胞。我们报告了首例AIDS患者T细胞PCNSL的完整临床描述。该患者对小脑病变进行了立体定向活检，免疫组化染色显示为T细胞淋巴瘤。患者在部分放射治疗后死于机会性感染。完整尸检未发现残留T细胞淋巴瘤的证据。作者比较了患有和未患有AIDS患者的T细胞PCNSL，并讨论了T细胞和B细胞PCNSL之间的差异。总之，T细胞PCNSL可发生于AIDS患者。肿瘤常位于幕下，似乎对放疗敏感。然而，患者生存期短，因为死亡通常由机会性感染而非淋巴瘤的占位效应所致。
