采用电子捕获气相色谱法测定血浆中劳拉西泮的含量。
Determination of lorazepam in plasma by electron capture GLC.
作者信息
de Groot G, Maes R A, Lemmens H H
出版信息
Arch Toxicol. 1976 Jun 8;35(3):229-34. doi: 10.1007/BF00293571.
PMID:9050
Abstract
A method is described for the determination of lorazepam plasma levels involving extraction from the sample and analysis of the intact lorazepam by electron capture gas-liquid chromatography. Using mass spectrometry it is demonstrated, that lorazepam shows a thermal rearrangement under gas chromatographic conditions. The limit of detection is 0.01 mg/l and the assay shows a linearity from 0.01-0.80 mg lorazepam per liter of plasma.
摘要
描述了一种测定劳拉西泮血浆浓度的方法，该方法包括从样品中提取以及通过电子捕获气液色谱法对完整的劳拉西泮进行分析。使用质谱法证明，劳拉西泮在气相色谱条件下会发生热重排。检测限为0.01毫克/升，该测定法在每升血浆中0.01 - 0.80毫克劳拉西泮范围内呈线性。
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