McCracken G H, Threlkeld N, Thomas M L
Pediatrics. 1977 Oct;60(4):463-6.
The pharmacokinetics of kanamycin and gentamicin were studied after intramuscular (IM) and intravenous (IV) (constant infusion over 20 minutes) administration in newborn infants. The serum concentrations, half-lives, area-under-the-curve values, and volumes of distribution were similar for each drug after both routes of administration. Based on these pharmacological similarities, it is likely that these aminoglycosides can be given safely and effectively as constant IV infusions to neonates in whom IM injections are not feasible.
在新生儿中，对卡那霉素和庆大霉素进行了肌内注射（IM）和静脉注射（IV，20分钟持续输注）后的药代动力学研究。两种给药途径后，每种药物的血清浓度、半衰期、曲线下面积值和分布容积均相似。基于这些药理学相似性，对于无法进行肌内注射的新生儿，以静脉持续输注的方式安全有效地给予这些氨基糖苷类药物是可行的。
