Gonera R K, Timmerhuis T P, Leyten A C, van der Heul C
Department of Internal Medicine, St. Elisabeth Hospital, Tilburg, Netherlands.
Neth J Med. 1997 Feb;50(2):88-91. doi: 10.1016/s0300-2977(96)00074-5.
A 30-year-old woman is described with both a cerebral venous thrombosis and a deep vein thrombosis of her leg in association with an exacerbation of her ulcerative colitis. Laboratory investigations revealed a transient functional APC resistance, without Factor V mutation, and a mild hyperhomocysteinaemia. After colectomy the APC ratio was normal. These findings may form a partial explanation of the thrombophilia seen in some patients with active ulcerative colitis.
