Nudelman Rodolfo Jose, Rosen Daniel Gustavo, Rouah Emilie, Verstovsek Gordana
Department of Pathology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77025, USA.
Patholog Res Int. 2010 Apr 29;2010:132754. doi: 10.4061/2010/132754.
Cerebral sinus thrombosis has been reported as an uncommon complication of ulcerative colitis (UC), occurring in up to 7.5% of cases. It is suspected to be a consequence of genetic predisposition and the hypercoagulable state occurring during disease relapse. We report a case of a 23-year-old male patient with one-year history of UC. He presented to the Emergency Room with left-sided progressive hemiparesis, numbness, hemiparesthesia, and pain, which followed a recent exacerbation of UC. The patient died 3 days after admission and an autopsy revealed superior and inferior sagittal sinus and cortical vein thrombosis with associated cerebral edema, hemorrhagic infarction, and herniation. The gastrointestinal tract had continuous cobblestone appearance extending from rectum to cecum, with hemorrhage and ulceration, consistent with active UC. Awareness of this rare complication of UC can contribute to early recognition and attempts at treatment of this serious and often fatal condition.
脑窦血栓形成已被报道为溃疡性结肠炎（UC）的一种罕见并发症，发生率高达7.5%。它被怀疑是遗传易感性和疾病复发期间出现的高凝状态的结果。我们报告一例23岁男性UC患者，病史1年。他因近期UC病情加重后出现左侧进行性偏瘫、麻木、偏身感觉异常和疼痛而就诊于急诊室。患者入院3天后死亡，尸检显示上矢状窦和下矢状窦及皮质静脉血栓形成，并伴有脑水肿、出血性梗死和脑疝。胃肠道从直肠至盲肠呈连续性鹅卵石样外观，伴有出血和溃疡，符合活动性UC表现。认识到UC的这种罕见并发症有助于早期识别并尝试治疗这种严重且往往致命的疾病。
