Dragos V, Lunder M
University Medical Centre Ljubljana, Department of Dermatology, Slovenia.
Pediatr Dermatol. 1997 Jan-Feb;14(1):46-8. doi: 10.1111/j.1525-1470.1997.tb00427.x.
Twenty-two children aged 2 to 9 years with noninflammatory tinea capitis due to Microsporum canis were evaluated in an open clinical pilot study run from January 1994 to July 1995. Each child was given oral terbinafine according to body weight for 6 weeks. Mycologic evaluation was done at the end of treatment and after follow-up periods of 4 and 8 weeks. None of the patients achieved complete mycologic cure by the end of the treatment period. Four weeks later complete mycologic cure was established in nine patients, and on final evaluation in seven. The treatment was very well tolerated by all the children. No systemic adverse effects were noted. According to our data, a 6-week course of oral terbinafine is inadequate for tinea capitis due to M. canis in children. Further study is needed to determine the most appropriate duration of therapy.
1994年1月至1995年7月进行的一项开放性临床试点研究中，对22名2至9岁因犬小孢子菌引起的非炎症性头癣儿童进行了评估。每个孩子根据体重口服特比萘芬6周。在治疗结束时以及4周和8周的随访期后进行真菌学评估。在治疗期结束时，没有患者实现完全真菌学治愈。4周后，9名患者实现了完全真菌学治愈，最终评估时有7名患者实现了完全真菌学治愈。所有儿童对该治疗的耐受性都很好。未观察到全身不良反应。根据我们的数据，6周疗程的口服特比萘芬对于儿童犬小孢子菌性头癣来说疗程不足。需要进一步研究以确定最合适的治疗疗程。
