“内质网驻留”分子伴侣的表面表达揭示未成熟胸腺细胞中内质网保留不完整
Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of "ER-resident" molecular chaperones.
作者信息
Wiest D L, Bhandoola A, Punt J, Kreibich G, McKean D, Singer A
机构信息
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1884-9. doi: 10.1073/pnas.94.5.1884.
Abstract
The folding and assembly of nascent proteins in the endoplasmic reticulum (ER) is assisted by molecular chaperones that are themselves retained within the ER. We now report that a number of different ER proteins, including molecular chaperones, are selectively expressed on the surface of immature thymocytes, but their surface expression is extinguished upon further differentiation. Escape from the ER is only possible for newly synthesized ER proteins before they become permanently retained. Thus, the cellular process of ER retention is incomplete in immature thymocytes and provides an explanation for surface expression of partial receptor complexes that transduce differentiative signals during thymic development.
摘要
内质网（ER）中新生蛋白质的折叠和组装由自身保留在内质网中的分子伴侣协助完成。我们现在报告，包括分子伴侣在内的许多不同的内质网蛋白在未成熟胸腺细胞表面选择性表达，但其表面表达在进一步分化时消失。只有新合成的内质网蛋白在永久保留之前才有可能逃离内质网。因此，内质网保留的细胞过程在未成熟胸腺细胞中是不完整的，这为在胸腺发育过程中传导分化信号的部分受体复合物的表面表达提供了解释。
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Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of "ER-resident" molecular chaperones.“内质网驻留”分子伴侣的表面表达揭示未成熟胸腺细胞中内质网保留不完整
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