通过荧光原位杂交（FISH）评估的一名47,XYY男性中，二体性精核发生率增加。

Increased incidence of disomic sperm nuclei in a 47,XYY male assessed by fluorescent in situ hybridization (FISH).

作者信息

Blanco J, Rubio C, Simon C, Egozcue J, Vidal F

机构信息

Unitat de Biologia Cellular, Facultat de Ciències, Universitat Autònoma de Barcelona, Bellaterra, Spain.

出版信息

Hum Genet. 1997 Mar;99(3):413-6. doi: 10.1007/s004390050381.

DOI:10.1007/s004390050381

PMID:9050932

Abstract

Using triple-colour fluorescent in situ hybridization in decondensed sperm heads, we assessed the sex-chromosome distribution in spermatozoa from a 47,XYY male compared with controls. The incidence of spermatozoa with 24,XY (0.30%) and 24,YY (1.01%) disomy was significantly higher than in our control series. Diploid meiocytes present in the ejaculate were mainly 47,XYY (60.6-86.7%), and haploid meiocytes were mainly 24,XY (78.1%).These results suggest that, although the extra Y chromosome is thought to be eliminated during spermatogenesis, XYY germ cells can complete meiosis and produce disomic spermatozoa.

摘要

我们使用三色荧光原位杂交技术对去浓缩精子头部进行检测，评估了一名47,XYY男性精子中性染色体的分布情况，并与对照组进行了比较。与对照组相比，具有24,XY（0.30%）和24,YY（1.01%）二体性的精子发生率显著更高。射精中的二倍体减数分裂细胞主要为47,XYY（60.6 - 86.7%），单倍体减数分裂细胞主要为24,XY（78.1%）。这些结果表明，尽管额外的Y染色体被认为在精子发生过程中会被消除，但XYY生殖细胞能够完成减数分裂并产生二体性精子。