使用血池造影剂增强的磁共振成像鉴别肝血管瘤与转移瘤及肝细胞癌代码-7227

Differentiation of liver hemangiomas from metastases and hepatocellular carcinoma at MR imaging enhanced with blood-pool contrast agent Code-7227.

作者信息

Harisinghani M G, Saini S, Weissleder R, Halpern E F, Schima W, Rubin D L, Stillman A E, Sica G T, Small W C, Hahn P F

机构信息

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114 USA.

出版信息

Radiology. 1997 Mar;202(3):687-91. doi: 10.1148/radiology.202.3.9051017.

DOI:10.1148/radiology.202.3.9051017

PMID:9051017

Abstract

PURPOSE

To evaluate differentiation of liver lesions at magnetic resonance (MR) imaging enhanced with Code-7227.

MATERIALS AND METHODS

Thirty-five patients with 38 proved liver lesions (15 hemangiomas, 17 metastases, six hepatocellular carcinomas [HCCs]) underwent T1-weighted gradient-echo and T2-weighted fast-spin-echo MR imaging at 1.5 T before and after intravenous administration of Code-7227 (1.1 mg iron per kilogram of body weight).

RESULTS

In hemangiomas, the mean contrast-to-noise ratio on precontrast and postcontrast images, respectively, increased from -4.51 +/- 4.7 (standard deviation) to 5.19 +/- 6.3 on T1-weighted images and decreased from 14.73 +/- 7.4 to 0.64 +/- 5.1 on T2-weighted images. In comparison, metastases remained hypointense to liver on T1-weighted images (from -5.77 +/- 5.9 to -7.8 +/- 6.8) and hyperintense on T2-weighted images (from 8.73 +/- 5.4 to 12.61 +/- 6.1). Although HCC enhanced more than metastases, they also remained hypointense to liver on T1-weighted images (from -4.87 +/- 6.1 to -1.79 +/- 5.7) and hyperintense on T2-weighted images (from 10.12 +/- 7.9 to 8.7 +/- 6.4). The degree of enhancement on T1-weighted images and of signal intensity drop on T2-weighted images were significantly lower in malignant liver masses than in hemangiomas (P < .001).

CONCLUSION

Distinctly different enhancement patterns with Code-7227 helped accurate differentiation of liver lesions.

摘要

目的

评估使用Code - 7227增强的磁共振（MR）成像对肝脏病变的鉴别诊断能力。

材料与方法

35例患者共38个经证实的肝脏病变（15个血管瘤、17个转移瘤、6个肝细胞癌[HCC]），在静脉注射Code - 7227（每千克体重1.1毫克铁）前后，于1.5 T行T1加权梯度回波和T2加权快速自旋回波MR成像。

结果

在血管瘤中，T1加权图像上对比剂前、后图像的平均对比噪声比分别从-4.51±4.7（标准差）增至5.19±6.3，T2加权图像上从14.73±7.4降至0.64±5.1。相比之下，转移瘤在T1加权图像上对肝脏仍呈低信号（从-5.77±5.9降至-7.8±6.8），在T2加权图像上呈高信号（从8.73±5.4增至12.61±6.1）。虽然HCC的强化程度高于转移瘤，但在T1加权图像上对肝脏也仍呈低信号（从-4.87±6.1降至-1.79±5.7），在T2加权图像上呈高信号（从10.12±7.9降至8.7±6.4）。恶性肝肿块在T1加权图像上的强化程度及T2加权图像上信号强度下降程度均显著低于血管瘤（P <.001）。