F3肽缀合氧化铁纳米颗粒细胞摄取行为的表面电荷研究
A surface-charge study on cellular-uptake behavior of F3-peptide-conjugated iron oxide nanoparticles.
作者信息
Zhang Yu, Yang Mo, Park Ji-Ho, Singelyn Jennifer, Ma Huiqing, Sailor Michael J, Ruoslahti Erkki, Ozkan Mihrimah, Ozkan Cengiz
机构信息
Department of Mechanical Engineering, University of California at Riverside, Riverside, CA 92521, USA.
出版信息
Small. 2009 Sep;5(17):1990-6. doi: 10.1002/smll.200900520.
Abstract
Surface-charge measurements of mammalian cells in terms of Zeta potential are demonstrated as a useful biological characteristic in identifying cellular interactions with specific nanomaterials. A theoretical model of the changes in Zeta potential of cells after incubation with nanoparticles is established to predict the possible patterns of Zeta-potential change to reveal the binding and internalization effects. The experimental results show a distinct pattern of Zeta-potential change that allows the discrimination of human normal breast epithelial cells (MCF-10A) from human cancer breast epithelial cells (MCF-7) when the cells are incubated with dextran coated iron oxide nanoparticles that contain tumor-homing F3 peptides, where the tumor-homing F3 peptide specifically bound to nucleolin receptors that are overexpressed in cancer breast cells.
摘要
通过zeta电位对哺乳动物细胞进行表面电荷测量，被证明是识别细胞与特定纳米材料相互作用的一种有用的生物学特性。建立了纳米颗粒孵育后细胞zeta电位变化的理论模型，以预测zeta电位变化的可能模式，从而揭示结合和内化效应。实验结果显示出一种独特的zeta电位变化模式，当用含有肿瘤归巢F3肽的葡聚糖包被氧化铁纳米颗粒孵育细胞时，这种模式能够区分人正常乳腺上皮细胞（MCF-10A）和人癌性乳腺上皮细胞（MCF-7），其中肿瘤归巢F3肽特异性结合在癌性乳腺细胞中过度表达的核仁素受体上。
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