4-（对氯苯硫基）丁醇（W-2719），一种用于速发型超敏反应性过敏的新型非抗组胺药物。
4-(p-Chlorophenylthio)butanol (W-2719), a new non-antihistaminic drug for immediate hypersensitivity allergies.
作者信息
Fukui G M, Ludwig B J, Sofia R D, Reisner D B, Berger F M
出版信息
Arzneimittelforschung. 1979;29(6):912-7.
PMID:90512
Abstract
p-Chlorophenylthiobutanol (W-2719) has been found to effectively inhibit immunologic and non-immunologic histamine release and mast cell degranulation. It has been found to effectively suppress passive cutaneous anaphylaxis (PCA) reaction not be antihistaminic action, but by inhibiting the release of allergic mediators.
摘要
对氯苯基硫代丁醇（W - 2719）已被发现能有效抑制免疫性和非免疫性组胺释放以及肥大细胞脱颗粒。已发现它能有效抑制被动皮肤过敏反应（PCA），其作用并非通过抗组胺作用，而是通过抑制过敏介质的释放。
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