基质金属蛋白酶
Matrix metalloproteinases.
作者信息
Parsons S L, Watson S A, Brown P D, Collins H M, Steele R J
机构信息
Department of Surgery, University Hospital, Nottingham, UK.
出版信息
Br J Surg. 1997 Feb;84(2):160-6.
BACKGROUND
The matrix metalloproteinases (MMPs) have a role in gastrointestinal malignancy. This role is reviewed, with particular reference to the gelatinase subgroup of enzymes.
METHODS
All relevant papers derived from the Medline and Enbase databases between 1984 and early 1996 were reviewed.
RESULT AND CONCLUSION
There is now strong evidence that MMPs play a major role in tumour invasion and metastasis. The development of MMP inhibitors may lead to important new treatment for the control of malignant disease.
背景
基质金属蛋白酶（MMPs）在胃肠道恶性肿瘤中发挥作用。本文对这一作用进行综述，特别提及明胶酶亚组的酶。
方法
回顾了1984年至1996年初从Medline和Embase数据库中获取的所有相关论文。
结果与结论
现在有强有力的证据表明MMPs在肿瘤侵袭和转移中起主要作用。MMP抑制剂的开发可能会带来控制恶性疾病的重要新疗法。
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