[Effect of bile acids and other surface-active substances on antidiuretic hormone regulation of epithelial membrane permeability].

Surfactants in low concentrations (1.10(-5) and 1.10(-4) g/ml) altered the action of the antidiuretic hormone on the permeability of the wall of frog urinary bladder. Anionogenic sodium cholate, nonionogenic twin-80 and cationoactive ethonium depressed the action of the antidiuretic hormone. Polyampholite eBM-4 enhanced the effect of the antidiuretic hormone. The effect of saponin depended on the concentration of the preparation. Of interest is a possibility of using the surfactants for influencing the mechanisms regulating water balance in the organism.