Moses P L, Krawitt E L, Aziz W, Corwin H L
Department of Medicine, University of Vermont College of Medicine, FAHC, Burlington 05405-0068, USA.
Dig Dis Sci. 1997 Feb;42(2):443-6. doi: 10.1023/a:1018803027109.
Hepatitis C virus infection can result in mixed cryoglobulinemia and associated clinical syndromes including membranoproliferative glomerulonephritis. Reports regarding the efficacy of interferon-alpha (IFN-alpha) in the treatment of patients with membranoproliferative glomerulonephritis and chronic hepatitis C infection have been inconclusive regarding improvement of renal function. We describe two patients with chronic hepatitis secondary to hepatitis C virus complicated by mixed cryoglobulinemia and membranoproliferative glomerulonephritis who developed severe renal failure which resolved after treatment with standard doses of IFN-alpha 2b.
丙型肝炎病毒感染可导致混合性冷球蛋白血症及相关临床综合征，包括膜增生性肾小球肾炎。关于α干扰素（IFN-α）治疗膜增生性肾小球肾炎合并慢性丙型肝炎感染患者的疗效，在肾功能改善方面的报道尚无定论。我们描述了两名继发于丙型肝炎病毒的慢性肝炎患者，他们合并混合性冷球蛋白血症和膜增生性肾小球肾炎，出现了严重肾衰竭，在接受标准剂量的IFN-α 2b治疗后病情得到缓解。
