Feldman J G, Chirgwin K, Dehovitz J A, Minkoff H
Department of Preventive Medicine, State University of New York, Health Science Center at Brooklyn, USA.
Obstet Gynecol. 1997 Mar;89(3):346-50. doi: 10.1016/S0029-7844(97)00011-2.
To determine the relation between cigarette smoking and the incidence of genital warts in a cohort of human immunodeficiency virus (HIV)-infected women (without AIDS-defining conditions) (n = 148) and in HIV-negative women (n = 428).
Women were recruited between March 1990 and December 1993 from an urban, inner-city medical center and nearby community health centers. Woman initially free of genital warts (n = 576) were followed prospectively for up to 37 months, with an average of 14 months.
The observed incidence of genital warts per 100 person-years was almost three times higher in smokers than in non-smokers, both in HIV-positive (13.3 versus 5.0, respectively) and HIV-negative women (1.5 versus 0.5, respectively). In a Poisson regression model adjusting for variables significantly related to genital warts, including sexual activity, current smokers were 5.2 times (95% confidence interval 1.02, 26.0) more likely to develop genital warts. The prevalence of human papillomavirus (HPV) by polymerase chain reaction at baseline examination and the incidence of other sexually transmitted diseases were similar is smokers and non-smokers.
Our findings are compatible with the hypothesis that the rate of progression of symptomatic exophytic HPV disease is increased in smokers.
确定在一组感染人类免疫缺陷病毒（HIV）的女性（无艾滋病界定条件）（n = 148）和HIV阴性女性（n = 428）中，吸烟与尖锐湿疣发病率之间的关系。
1990年3月至1993年12月期间，从城市中心的医疗中心和附近社区卫生中心招募女性。最初无尖锐湿疣的女性（n = 576）被前瞻性随访长达37个月，平均随访14个月。
每100人年尖锐湿疣的观察发病率，在吸烟者中几乎是非吸烟者的三倍，在HIV阳性女性（分别为13.3和5.0）和HIV阴性女性（分别为1.5和0.5）中均如此。在对与尖锐湿疣显著相关的变量（包括性活动）进行调整的泊松回归模型中，当前吸烟者发生尖锐湿疣的可能性高5.2倍（95%置信区间1.02, 26.0）。在基线检查时通过聚合酶链反应检测的人乳头瘤病毒（HPV）患病率以及其他性传播疾病的发病率，在吸烟者和非吸烟者中相似。
我们的研究结果与以下假设相符，即吸烟者有症状的外生性HPV疾病进展速度加快。
