Adrenomedullin: a new peptide involved in cardiorenal homeostasis?
作者信息
Edwards R M, Trizna W, Aiyar N
机构信息
Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939, USA.
出版信息
Exp Nephrol. 1997 Jan-Feb;5(1):18-22.
PMID:9052844
Abstract
Adrenomedullin (ADM) was originally discovered in human pheochromocytoma but is now known to be widely distributed in various organs including the kidney. ADM is a potent hypotensive peptide that increases renal blood flow and causes natriuresis and diuresis. While ADM may act in a paracrine manner, circulating levels are increased in hypertension, chronic renal failure and congestive heart failure. Current evidence suggests that ADM may play an important role in cardiorenal homeostasis.
摘要
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