Boklage C E
Department of Pediatrics, School of Medicine, East Carolina University, Greenville, NC 27858-4354, USA.
Hum Reprod. 1996 Oct;11(10):2276-84. doi: 10.1093/oxfordjournals.humrep.a019089.
This paper concerns a behaviour-driven weekday rhythm in conception rates in a large natural human population. From 1978 to 1991, North Carolina normal live single births arose from menstrual cycles which began on Monday in clear excess over other weekdays. Cycles beginning on Friday were also in excess. Cycles starting on Saturday and Sunday, or Wednesday and Thursday, each represented significantly less than one in seven of weekly totals. The source of the observed synchrony was a Sunday morning peak of coital frequency. Average cycles which began on Monday had their most fertile day on the most likely day for intercourse, translating a weekly insemination rhythm into a weekly conception rate rhythm. The secondary conception peak in Friday-onset cycles increased with age, to become the major peak for mothers aged > 30 years. We interpret this to represent a previously unreported second type of cycle with a modal follicular phase length of 10 days, the frequency of which increases with age. Several large groups of anomalous human births depart significantly from the weekday rhythm of normal conceptions. These outcomes parallel results of experimental interference with fertilization timing in estruative mammals. We believe that this implicates anomalous fertilization timing in several of the most numerous anomalies of human prenatal development.
本文关注的是在一个大型自然人群中，受孕率的行为驱动的工作日节律。1978年至1991年期间，北卡罗来纳州正常的单胎活产来自于始于周一的月经周期，这一周期明显多于其他工作日开始的周期。始于周五的周期也有所增加。始于周六和周日，或周三和周四的周期，各自在每周总数中所占比例明显不到七分之一。观察到的同步性来源是周日早晨性交频率的峰值。始于周一的平均周期在最有可能进行性交的那天迎来最易受孕的日子，从而将每周的授精节律转化为每周的受孕率节律。周五开始的周期中的次要受孕高峰随着年龄增长而增加，对于30岁以上的母亲来说成为主要高峰。我们将此解释为代表了一种先前未报告的第二种类型的周期，其卵泡期长度模式为10天，其频率随年龄增加。几组大量的异常人类出生情况明显偏离了正常受孕的工作日节律。这些结果与对处于发情期的哺乳动物受精时间进行实验干扰的结果相似。我们认为，这意味着在人类产前发育中一些最为常见的异常情况中存在异常的受精时间。
