Strobino B, Kline J, Warburton D
Epidemiology of Brain Disorders Research Unit, New York State Psychiatric Institute.
Am J Public Health. 1988 Mar;78(3):260-3. doi: 10.2105/ajph.78.3.260.
The relation between periconceptional vaginal spermicide use and sex ratio at birth, birthweight, and the frequency of congenital anomalies was examined in a cohort of 2,712 New York City obstetric patients, 149 of whom (5.5 per cent) became pregnant while using spermicides or had used spermicides before and after conception. Periconceptional spermicide use was not associated with any important variation in the expected sex ratio at birth, nor with major or minor congenital anomalies. Exposure to spermicides in the periconceptional period, defined dichotomously as present or absent, was not associated with decreased birthweight in male or female infants. There was a slight decrease in birthweight among female infants with increasing duration of postconceptional spermicide use; an estimated 7.4 grams decrease with each day of use. The size of the effect and its selectivity by sex suggest a chance finding.
在一组2712名纽约市产科患者中，研究了受孕前后使用阴道杀精剂与出生性别比、出生体重以及先天性异常发生率之间的关系。其中149名患者（5.5%）在使用杀精剂期间怀孕，或在受孕前后使用过杀精剂。受孕前后使用杀精剂与预期出生性别比的任何重要变化均无关联，也与主要或次要先天性异常无关。将受孕期间接触杀精剂分为接触或未接触两种情况，这与男婴或女婴出生体重降低无关。随着受孕后使用杀精剂时间的延长，女婴出生体重略有下降；估计每天使用杀精剂会使出生体重下降7.4克。这种影响的大小及其性别选择性表明这是一个偶然发现。
