Sanders D Y, Thompson J R, Carlton F B
University of Mississippi Medical Center, USA.
J Miss State Med Assoc. 1996 Feb;37(2):471-5.
The purpose of the current manuscript is to familiarize the primary physician with the presentation of phenytoin hypersensitivity syndrome, and to discuss management options. A review of all admissions to the University of Mississippi Medical Center over a five year period revealed 4 cases of phenytoin hypersensitivity syndrome. These cases are presented and the phenytoin hypersensitivity syndrome, characterized most commonly by fever, cutaneous eruption and lymphadenopathy, is described. It is emphasized that the clinician must be aware of the syndrome and must recognize it on presentation. Theories regarding etiology and treatment options are discussed. It is recommended that all patients with symptoms of phenytoin hypersensitivity syndrome be hospitalized and that steroids be initiated.
本手稿的目的是让基层医生熟悉苯妥英钠超敏反应综合征的表现，并讨论其处理方法。对密西西比大学医学中心五年内所有入院病例的回顾显示，有4例苯妥英钠超敏反应综合征。现展示这些病例，并描述以发热、皮疹和淋巴结病最为常见的苯妥英钠超敏反应综合征。强调临床医生必须了解该综合征，且在出现症状时必须能够识别。文中讨论了病因及治疗方法的相关理论。建议所有有苯妥英钠超敏反应综合征症状的患者住院，并开始使用类固醇治疗。
