Rengo F, Canonico V
Cattedra di Geriatria, Policlinici Pansini, Napoli.
Minerva Cardioangiol. 1996 Dec;44(12):631-5.
The aim of the study was to evaluate efficacy and tolerability of quinapril 20 mg once-a-day versus lisinopril 20 mg, in the treatment of old patients suffering from essential mild or moderate hypertension and presenting low levels of plasmarenin. It was a cross-over study with open treatments randomly assigned. Ten patients were treated, 6 females and 4 males, with average age of 67.1 years +/- 7.1. Two wash-out periods with placebo were scheduled, each lasting one week before the onset of active therapy; each treatment period lasted 21 days. Blood pressure controls (including the 24 hours monitoring) were done at basal time, after seven days and at the end of each treatment. Results show the efficacy and the safety of both the drugs and a more effective and constant control of hypertension by Quinapril was confirmed.
该研究的目的是评估每日一次服用20毫克喹那普利与20毫克赖诺普利在治疗患有原发性轻度或中度高血压且血浆肾素水平较低的老年患者中的疗效和耐受性。这是一项开放治疗随机分配的交叉研究。共治疗了10名患者，其中6名女性和4名男性，平均年龄为67.1岁±7.1岁。安排了两个为期一周的安慰剂洗脱期，分别在积极治疗开始前进行；每个治疗期持续21天。在基线期、七天后以及每个治疗结束时进行血压控制（包括24小时监测）。结果显示了两种药物的疗效和安全性，并证实喹那普利对高血压的控制更有效且持续。
