Vinogradova E P, Poliakova O N, Batuev A S
Zh Vyssh Nerv Deiat Im I P Pavlova. 1996 Nov-Dec;46(6):1097-103.
Behaviour was studied of the offsprings of female rats which were exposed to pain (P) and emotional (PSY) stress during the last 9 days of pregnancy. The P group received 5 electrical foot shocks (shuffle threshold, 50 Hz, 3 sec). PSY rats were placed in the compartment adjacent with the grid-floor box, thus they could watch, hear and smell the mate exposed to P. Pups of the intact rats served as a control (C). At 7-8 weeks of age the offsprings were tested in a modified Morris maze. Performance was significantly better in the P group than in the PSY and C groups. Acquisition of avoidance in a one-way shuttle-box at 10-12 weeks was higher in the P group than in the PSY and C animals. Two weeks later, the C rats were more successful in acquisition in a two-way shuttle-box than the PSY and P rats. At the age of 4-5 months a trend was revealed to higher capacity for learning in female P and C offsprings than in males while in the PSY group capacity for learning was sex-independent. The findings suggest that the pain and emotional stress during pregnancy exert different effects on behaviour of the offsprings.
对在妊娠最后9天暴露于疼痛（P）和情绪（PSY）应激的雌性大鼠的后代行为进行了研究。P组接受5次电足部电击（随机阈值，50Hz，3秒）。PSY组大鼠被放置在与网格地板箱相邻的隔室中，因此它们可以观看、听到并闻到暴露于P的同伴的情况。完整大鼠的幼崽作为对照（C）。在7-8周龄时，对后代在改良的莫里斯迷宫中进行测试。P组的表现明显优于PSY组和C组。在10-12周龄时，P组在单向穿梭箱中获得回避的能力高于PSY组和C组动物。两周后，C组大鼠在双向穿梭箱中的习得成功率高于PSY组和P组大鼠。在4-5个月龄时，发现雌性P组和C组后代的学习能力高于雄性，而在PSY组中，学习能力与性别无关。研究结果表明，孕期的疼痛和情绪应激对后代行为有不同影响。
