Davydov V Iu, Kulik L N, Kisel' M A
Antibiot Khimioter. 1996 May;41(5):25-9.
Antibiotic entrapment to liposomes containing phosphatidyl ethanol, a negatively charged phospholipid, as a lipid component was studied. Antibiotics of various groups such as doxorubicin, rifampicin and doxycycline were entrapped to liposomes consisting of a mixture of phosphatidyl choline and phosphatidyl ethanol at a ratio of 1:1 (v/v) or phosphatidyl choline alone. It was shown that the liposomes containing phosphatidyl ethanol were able to entrap the antibiotics in higher amounts by comparison with the liposomes containing phosphatidyl choline. Phosphatidyl ethanol in the composition of the liposomes had the highest effect on the entrapment of doxorubicin.
研究了将抗生素包封到含有磷脂酰乙醇（一种带负电荷的磷脂）作为脂质成分的脂质体中的情况。将不同种类的抗生素如阿霉素、利福平和强力霉素包封到由磷脂酰胆碱和磷脂酰乙醇按1:1（v/v）比例混合组成的脂质体中，或单独包封到磷脂酰胆碱脂质体中。结果表明，与含有磷脂酰胆碱的脂质体相比，含有磷脂酰乙醇的脂质体能够包封更多量的抗生素。脂质体组成中的磷脂酰乙醇对阿霉素的包封效果最为显著。
