Jin J Y, Tooze J A, Marsh J C, Gordon-Smith E C
Department of Cellular and Molecular Sciences, St George's Hospital Medical School, London.
Br J Haematol. 1997 Mar;96(3):493-6. doi: 10.1046/j.1365-2141.1997.d01-2047.x.
Deficiencies in glycosylphosphatidyl-inositol (GPI)-linked proteins on erythrocytes and leucocytes in patients with paroxysmal nocturnal haemoglobinuria (PNH) are well known; however, expression on platelets in these patients is less well documented. We have studied CD55 and CD59 on the platelets of PNH and aplastic anaemia (AA) patients using flow cytometry. In all cases of PNH, CD55 and CD59 negative populations of platelets were detected with single or bimodal distribution and these results showed close correlation with the CD55 and CD59 patterns of neutrophils. Previous published studies have not demonstrated this distribution. We suggest that our findings may be due to the methodology used.
阵发性夜间血红蛋白尿（PNH）患者红细胞和白细胞上糖基磷脂酰肌醇（GPI）连接蛋白的缺陷是众所周知的；然而，这些患者血小板上的表达情况记录较少。我们使用流式细胞术研究了PNH和再生障碍性贫血（AA）患者血小板上的CD55和CD59。在所有PNH病例中，均检测到血小板的CD55和CD59阴性群体呈单峰或双峰分布，这些结果与中性粒细胞的CD55和CD59模式密切相关。先前发表的研究并未证明这种分布情况。我们认为我们的发现可能归因于所使用的方法。
