Guo S W
Department of Biostatistics, University of Michigan, Ann Arbor 48109-2029, USA.
Genet Epidemiol. 1997;14(1):1-15. doi: 10.1002/(SICI)1098-2272(1997)14:1<1::AID-GEPI1>3.0.CO;2-C.
Homozygosity mapping is a very powerful method for mapping rare recessive diseases in humans. In many applications, it is often desirable to compute prior (or unconditional) multilocus probability of autozygosity for inbred pedigrees. This paper proposes a simple yet powerful method for computing the prior multilocus autozygosity probability for complex inbred pedigrees. The method has an added feature of providing explicit multilocus autozygosity probability in terms of recombination fractions, if desired. An example is presented to illustrate the method.
纯合性定位是一种在人类中定位罕见隐性疾病的非常强大的方法。在许多应用中，通常希望计算近亲家系中纯合性的先验（或无条件）多位点概率。本文提出了一种简单而强大的方法来计算复杂近亲家系的先验多位点纯合性概率。如果需要，该方法还具有根据重组率提供明确的多位点纯合性概率的附加功能。给出了一个例子来说明该方法。
