Khwarg S I, Yu H G, Yu Y S
Department of Ophthalmology, Seoul National University College of Medicine, Korea.
Korean J Ophthalmol. 1996 Dec;10(2):92-6. doi: 10.3341/kjo.1996.10.2.92.
Cryotherapy has been shown to be an effective treatment for retinopathy of prematurity (ROP) stage 3+. However, the outcome of cryotherapy is less favorable in zone 1 ROP than in zone 2 ROP. We suspected whether there may be differences in the outcomes of cryotherapy if the zone of ROP is further divided. So we reviewed the records of 85 premature infants (145 eyes) who had undergone cryotherapy for ROP. The frequencies of favorable outcome were 42.9% of 14 eyes (zone 1), 78.9% of 38 eyes (posterior zone 2), 92.9% of 70 eyes (mid zone 2), and 100.0% of 23 eyes (anterior zone 2), respectively (p < 0.001). These results suggest that the more posteriorly the ROP is located, the less favorable the outcome of cryotherapy.
冷冻疗法已被证明是治疗3期及以上早产儿视网膜病变（ROP）的有效方法。然而，与2区ROP相比，1区ROP的冷冻治疗效果较差。我们怀疑，如果将ROP区域进一步细分，冷冻治疗的结果是否会存在差异。因此，我们回顾了85例接受ROP冷冻治疗的早产儿（145只眼）的记录。14只眼（1区）的良好结局频率为42.9%，38只眼（2区后部）为78.9%，70只眼（2区中部）为92.9%，23只眼（2区前部）为100.0%（p<0.001）。这些结果表明，ROP位置越靠后，冷冻治疗的效果越差。
