Shaala S, Khowessah M, EL-Damarawy H, E-Sahwi S, Osman M, Toppozada M
Prostaglandins. 1977 Sep;14(3):523-33. doi: 10.1016/0090-6980(77)90266-0.
The effect of prostaglandin F2alpha (PGF2alpha) on the nonpregnant human uterus was evaluated in 35 patients. The compound was administered both by intra-uterine and intravenous routes. Two groups of volunteers were studied;fifteen cases who were under oral contraceptives and twenty women with normal ovulatory cycles. The uterus under the influence of oral contraceptives showed a reduced response to local and systemic administration of PGF2alpha at all phases of the menstrual cycle. The implications of these findings in certain physiological and pathological conditions related to reproduction are discussed.
在35例患者中评估了前列腺素F2α（PGF2α）对未孕人体子宫的作用。该化合物通过宫腔内和静脉途径给药。研究了两组志愿者；15例口服避孕药的患者和20例排卵周期正常的女性。受口服避孕药影响的子宫在月经周期的所有阶段对局部和全身给予PGF2α的反应均降低。讨论了这些发现在某些与生殖相关的生理和病理状况中的意义。
