O'Connor A D, Clifford P, Dalley V M, Durden-Smith D J, Edwards W G, Hollis B A
Clin Otolaryngol Allied Sci. 1979 Oct;4(5):329-37. doi: 10.1111/j.1365-2273.1979.tb01761.x.
The 4-year results of treatment of advanced squamous cell cancer of the head and neck regions by radiotherapy combined with a cytotoxic regimen VBM (Vincristine, Bleomycin, Methotrexate) given synchronously are compared with those obtained with radiotherapy alone in similar patients. There was a statistically significant improvement in the results of the combined treatment at four years in terms of crude survival rate (56.1% v. 24.5%) and disease free survival rate (56.5% v. 21.8%). Both groups are examined for general prognostic features which might account for the difference. In the absence of such features it must be concluded that the addition of VBM to radiotherapy had produced a marked therapeutic improvement.
将同步给予细胞毒性方案VBM（长春新碱、博来霉素、甲氨蝶呤）的放疗与单纯放疗对相似患者的晚期头颈部鳞状细胞癌进行治疗的4年结果进行比较。联合治疗组在4年时的总生存率（56.1%对24.5%）和无病生存率（56.5%对21.8%）方面有统计学意义的改善。对两组患者的一般预后特征进行检查，以解释可能存在的差异。若不存在此类特征，则必须得出结论，即放疗联合VBM可带来显著的治疗改善。
