Herrup K, Kuemerle B
Department of Neurology, Case Western Reserve School of Medicine, Cleveland, Ohio 44120, USA.
Annu Rev Neurosci. 1997;20:61-90. doi: 10.1146/annurev.neuro.20.1.61.
The concept of developmental compartments originated in studies of Drosophila embryogenesis. This review examines the hypothesis that the modular structure of the vertebrate cerebellum is strongly analogous to this earlier scheme. The pattern of cerebellar development, the adult circuitry, a variety of molecular markers expressed in specific subdivisions, and the phenotypes of several neurological mutations all provide abundant evidence that the vertebrate cerebellum is organized into modules. We present the case that, as a group, these markers reveal distinct boundaries that partition the cerebellum into true developmental compartments. Although this reductionist viewpoint advances our understanding of cerebellar organization, the relationship between these compartments and the functional behavior of the cerebellum remains a mystery.
发育区室的概念起源于对果蝇胚胎发育的研究。本综述探讨了这样一种假说，即脊椎动物小脑的模块化结构与这一早期模式极为相似。小脑的发育模式、成年后的神经回路、在特定亚区表达的多种分子标记以及几种神经学突变的表型，都提供了充分的证据表明脊椎动物小脑是由模块组成的。我们提出，作为一个整体，这些标记揭示了将小脑划分为真正发育区室的明显边界。尽管这种还原论观点推进了我们对小脑组织的理解，但这些区室与小脑功能行为之间的关系仍是一个谜。
