Nakielny S, Fischer U, Michael W M, Dreyfuss G
Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104-6148, USA.
Annu Rev Neurosci. 1997;20:269-301. doi: 10.1146/annurev.neuro.20.1.269.
RNA molecules synthesized in the nucleus are transported to their sites of function throughout the eukaryotic cell by specific transport pathways. This review focuses on transport of messenger RNA, small nuclear RNA, ribosomal RNA, and transfer RNA between the nucleus and the cytoplasm. The general molecular mechanisms involved in nucleocytoplasmic transport of RNA are only beginning to be understood. However, during the past few years, substantial progress has been made. A major theme that emerges from recent studies of RNA transport is that specific signals mediate the transport of each class of RNA, and these signals are provided largely by the specific proteins with which each RNA is associated.
在细胞核中合成的RNA分子通过特定的运输途径被转运到整个真核细胞的功能位点。本综述聚焦于信使RNA、小核RNA、核糖体RNA和转运RNA在细胞核与细胞质之间的运输。RNA核质运输所涉及的一般分子机制才刚刚开始被理解。然而,在过去几年中已经取得了实质性进展。最近对RNA运输的研究中出现的一个主要主题是,特定信号介导每一类RNA的运输,而这些信号很大程度上由与每种RNA相关的特定蛋白质提供。