人类肿瘤中HLA I类分子表型改变对免疫监视的影响。
Implications for immunosurveillance of altered HLA class I phenotypes in human tumours.
作者信息
Garrido F, Ruiz-Cabello F, Cabrera T, Pérez-Villar J J, López-Botet M, Duggan-Keen M, Stern P L
机构信息
Dpto de Análisis Clinicos e Inmunología, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Spain. Fgarrido@golialt. ugr.es
出版信息
Immunol Today. 1997 Feb;18(2):89-95. doi: 10.1016/s0167-5699(96)10075-x.
HLA class I downregulation is a frequent event associated with tumour invasion and development. Altered HLA class I tumour phenotypes can have profound effects on T-cell and natural killer (NK)-cell antitumour responses. Here, Federico Garrido and colleagues analyse these altered tumour phenotypes in detail, indicating their potential relevance for implementation of immunotherapeutic protocols and strategies to overcome tumour escape mechanisms.
HLA I类分子下调是一种与肿瘤侵袭和发展相关的常见现象。HLA I类分子肿瘤表型的改变可对T细胞和自然杀伤（NK）细胞的抗肿瘤反应产生深远影响。在此，费德里科·加里多及其同事详细分析了这些改变的肿瘤表型，指出了它们在实施免疫治疗方案和克服肿瘤逃逸机制策略方面的潜在相关性。
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