O'Connor H J, Cunnane K, Collins J S, Sloan J M, Johnston B T, Bamford K C, Gilvarry J, O'Morain C A
Department of Medicine, General Hospital, Tullamore.
Ir J Med Sci. 1997 Jan-Mar;166(1):32-4. doi: 10.1007/BF02939774.
In a prospective study designed to assess the effect of duration of antibiotic therapy on the helicobactericidal and ulcer healing efficacy of bismuth therapy, groups of patients, 10 in each group, with H. pylori-positive duodenal ulcer received a triple therapy regimen consisting of colloidal bismuth subcitrate 120 mg 4 times daily for 28 days with metronidazole 400 mg 3 times daily and tetracycline 500 mg 3 times daily for the first 3, 5 or 7 days of therapy. H. pylori infection was assessed by urease test, culture and histology performed before and 4 or more weeks after completion of therapy. Three patients (30 per cent) were H. pylori-negative after therapy in the 3 day compared with 5 (50 per cent) in the 5 day and 9 (90 per cent) in the 7 day treatment groups (3 vs 7, P = 0.01; 5 vs 7, P = 0.14). Healed ulcers were seen in 7 (70 per cent) of the 3 day, in 6 (60 per cent) of the 5 day, and in 10 (100 per cent) of the 7 day treatment groups (5 vs 7, P = 0.04). Bismuth triple therapy incorporating metronidazole and tetracycline for 7 days is associated with superior H. pylori eradication and ulcer healing rates than bismuth triple incorporating antibiotics for 3 or 5 days.
在一项旨在评估抗生素治疗时长对铋剂治疗幽门螺杆菌及溃疡愈合疗效影响的前瞻性研究中，每组10例幽门螺杆菌阳性十二指肠溃疡患者接受三联治疗方案，即枸橼酸铋钾120毫克，每日4次，共28天，同时在治疗的前3、5或7天联合甲硝唑400毫克，每日3次，四环素500毫克，每日3次。治疗前及治疗结束4周或更长时间后通过尿素酶试验、培养及组织学检查评估幽门螺杆菌感染情况。3天治疗组中有3例患者（30%）治疗后幽门螺杆菌呈阴性，5天治疗组为5例（50%），7天治疗组为9例（90%）（3天与7天组比较，P = 0.01；5天与7天组比较，P = 0.14）。3天治疗组7例（70%）溃疡愈合，5天治疗组6例（60%），7天治疗组10例（100%）（5天与7天组比较，P = 0.04）。与铋剂联合抗生素治疗3天或5天的三联疗法相比，铋剂联合甲硝唑和四环素治疗7天的三联疗法在幽门螺杆菌根除率及溃疡愈合率方面更优。
