O'Connor H J, Kanduru C, Bhutta A S, Meehan J M, Feeley K M, Cunnane K
Department of Medicine, General Hospital, Tullamore, Co Offaly, Eire.
Postgrad Med J. 1995 Feb;71(832):90-3. doi: 10.1136/pgmj.71.832.90.
In a prospective study designed to assess the effect of Helicobacter pylori eradication on peptic ulcer healing, 85 consecutive patients with H. pylori-positive peptic ulcer disease were treated with a triple therapy regimen consisting of colloidal bismuth subcitrate 120 mg four times daily for 28 days, with metronidazole 400 mg three times daily and tetracycline 500 mg three times daily for the first seven days of treatment. H. pylori status was assessed by CLO test and histology at least four weeks after completing therapy. Of 75 patients (88%) H. pylori-negative after therapy, 69 (92%) had healed ulcers compared with only five of 10 patients (50%) who remained H. pylori-positive (p = 0.003). Cigarette smoking had no significant effect on ulcer healing. Our results suggest that H. pylori eradication may accelerate ulcer healing and provide further evidence that an effective helicobactericidal regimen is the treatment of choice in H. pylori-positive peptic ulcer.
在一项旨在评估根除幽门螺杆菌对消化性溃疡愈合影响的前瞻性研究中，85例连续的幽门螺杆菌阳性消化性溃疡患者接受了三联疗法，即枸橼酸铋钾120毫克，每日4次，共28天，甲硝唑400毫克，每日3次，四环素500毫克，在治疗的前7天每日3次。在完成治疗至少4周后，通过CLO试验和组织学评估幽门螺杆菌状态。治疗后75例患者（88%）幽门螺杆菌阴性，其中69例（92%）溃疡愈合，而10例仍为幽门螺杆菌阳性的患者中只有5例（50%）溃疡愈合（p = 0.003）。吸烟对溃疡愈合无显著影响。我们的结果表明，根除幽门螺杆菌可能加速溃疡愈合，并进一步证明有效的杀幽门螺杆菌方案是幽门螺杆菌阳性消化性溃疡的首选治疗方法。
