Ngan S Y
Division of Radiation Oncology, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia.
Acta Orthop Scand Suppl. 1997 Feb;273:112-6. doi: 10.1080/17453674.1997.11744714.
The local treatment of soft tissue sarcoma is evolving. Limb-sparing compartmentectomy offers local control but at the expense of function and a high amputation rate. The functional outcome is improved with combined wide excision and radiotherapy, at the same time achieving a similar local control rate. Future directions should include attempts to reduce toxicity and maximise the functional result. As the limb function is ultimately related to the aggressiveness of the local treatment, the optimum surgical margin, radiation volume and dose, require further investigation. The pursuit of local control should not be compromised in the quest for reducing morbidity, as the relationship between local control and survival remains unclear.
软组织肉瘤的局部治疗正在不断发展。保肢的间室切除术可实现局部控制，但要以功能受损和高截肢率为代价。联合广泛切除和放疗可改善功能结局，同时实现相似的局部控制率。未来的发展方向应包括努力降低毒性并使功能结果最大化。由于肢体功能最终与局部治疗的侵袭性相关，最佳手术切缘、放疗范围和剂量仍需进一步研究。在追求降低发病率的过程中，不应牺牲对局部控制的追求，因为局部控制与生存之间的关系仍不明确。
