RUTH G R, Schwartz S, Stephenson B
Science. 1977 Oct 14;198(4313):199-201. doi: 10.1126/science.905823.
Protoporphyria, a photosensitizing disease documented only in humans, was transmitted as a recessive trait to seven female calves. Cutaneous lesions were extensive, and erythrocyte and fecal protoporphyrin concentrations exceeded by far those of human protoporphyria. Average ferrochelatase activity was decreased to one-half of normal in the liver of carriers, and to about one-tenth of normal in liver, kidney, heart, spleen, lung, and marrow of protoporphyrics.
原卟啉症是一种仅在人类中被记录的光敏性疾病，它作为一种隐性性状遗传给了七头雌性小牛。皮肤病变广泛，红细胞和粪便中原卟啉的浓度远远超过人类原卟啉症患者的浓度。携带者肝脏中的平均亚铁螯合酶活性降至正常的一半，而在原卟啉症患者的肝脏、肾脏、心脏、脾脏、肺和骨髓中则降至正常的约十分之一。
